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Related Concept Videos

Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...

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Related Experiment Video

Updated: May 26, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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DSM-5: proposed changes to depressive disorders.

Jerome C Wakefield

    Current Medical Research and Opinion
    |December 29, 2011
    PubMed
    Summary
    This summary is machine-generated.

    The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposed changes may lead to overdiagnosis of depressive disorders. While some new categories are needed, they risk mislabeling normal distress as mental illness.

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    Area of Science:

    • Psychiatry
    • Mental Health Diagnostics
    • Nosology

    Background:

    • The Diagnostic and Statistical Manual of Mental Disorders (DSM) is revising to its fifth edition (DSM-5) in 2013.
    • Proposed DSM-5 changes include new depressive disorder categories, raising concerns about 'false-positive diagnoses' of normal distress.
    • Mislabeling normal distress as mental disorder can impact clinical trials, research, resource allocation, and treatment decisions.

    Discussion:

    • Critically examines five proposed DSM-5 expansions: mixed anxiety/depression, premenstrual dysphoric disorder, and changes to bereavement exclusions for major depression and adjustment disorders.
    • Evaluates proposals for face validity, conceptual coherence, empirical support, and potential for false-positive diagnoses.
    • Analyzes the proposed new category for pathological non-depressive grief within adjustment disorders.

    Key Insights:

    • Mixed anxiety/depression and premenstrual dysphoric disorder are deemed necessary but potentially overbroad, risking substantial false positives.
    • Evidence does not support eliminating the bereavement exclusion for major depression.
    • Proposed changes to adjustment disorder bereavement exclusions and a new grief-related adjustment disorder category may pathologize normal grief.

    Outlook:

    • Further refinement of proposed DSM-5 categories is needed to minimize false positives.
    • Empirical research on grief and bereavement is crucial for accurate diagnostic criteria.
    • Careful consideration of diagnostic scope is essential to maintain the validity of mental health research and clinical practice.