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FOXP3 and TGF-β gene polymorphisms in allergic rhinitis
Hadi Hassannia1, Saeid Abediankenari, Javad Ghaffari
1Department of Immunology and Microbiology, Mazandaran University of Medical Sciences, Sari, Iran,
Background:
Regulatory CD4+ T (Treg) cells are effective in maintaining immune tolerance.
Objective:
To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR).
Methods:
Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated in AR patients and compared with controls. In a case-control study, 155 AR patients and 163 allergy-free controls were genotyped using polymerase chain reaction sequence-specific primer (PCR-SSP) technique.
Results:
The analysis of the frequency of these SNPs showed that the haplotype formed by FOXP3 -3279 A allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% CI=1.312-2.66; p=0.001).
Conclusion:
Our results suggest that polymorphism in FOXP3 gene is associated with susceptibility to AR.
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