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FOXP3 and TGF-β gene polymorphisms in allergic rhinitis.
Hadi Hassannia1, Saeid Abediankenari, Javad Ghaffari
1Department of Immunology and Microbiology, Mazandaran University of Medical Sciences, Sari, Iran,
Iranian Journal of Immunology : IJI
|December 29, 2011
Summary
Genetic variations in the Forkhead Box Protein 3 (FOXP3) gene are linked to an increased risk of allergic rhinitis (AR). This study identified specific FOXP3 polymorphisms associated with AR susceptibility in an Iranian population.
Area of Science:
- Immunogenetics
- Molecular Biology
- Allergy Research
Background:
- Regulatory T (Treg) cells are crucial for immune tolerance.
- Allergic rhinitis (AR) is an immune-mediated condition.
- Genetic factors play a role in AR development.
Purpose of the Study:
- To investigate single nucleotide polymorphisms (SNPs) in Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes.
- To determine the association of these gene variations with allergic rhinitis in an Iranian cohort.
Main Methods:
- A case-control study involving 155 AR patients and 163 allergy-free controls.
- Genotyping of TGF-β1 (codons 10, 25) and FOXP3 (positions -3279, -924) using polymerase chain reaction sequence-specific primer (PCR-SSP).
Main Results:
- A significant association was found between a specific FOXP3 gene haplotype (A allele at -3279) and AR.
- The FOXP3 -3279 A allele occurred more frequently in AR patients (OR=1.44, p=0.001).
Conclusions:
- Polymorphisms within the FOXP3 gene are associated with increased susceptibility to allergic rhinitis.
- FOXP3 gene variations may contribute to the development of AR.
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