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Related Experiment Video

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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HuR function in disease.

Subramanya Srikantan1, Myriam Gorospe

  • 1Laboratory of Molecular Biology and Immunology, NIA-IRP, NIH, Baltimore, MD 21224, USA.

Frontiers in Bioscience (Landmark Edition)
|December 29, 2011
PubMed
Summary

The RNA-binding protein HuR regulates gene expression by controlling mRNA stability and translation. Dysregulation of HuR impacts cellular responses and contributes to diseases like cancer and inflammation.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cytoplasmic events, including mRNA stability and translation, are crucial for mammalian gene expression and cellular responses.
  • HuR (Human antigen R) is a ubiquitous RNA-binding protein (RBP) that significantly influences cytoplasmic mRNA fate.
  • HuR's post-transcriptional regulation affects cellular responses to various stimuli like proliferation, stress, apoptosis, and inflammation.

Purpose of the Study:

  • To review the mechanisms controlling HuR function.
  • To elucidate HuR's influence on target mRNAs.
  • To examine the impact of impaired HuR-governed gene expression on disease processes.

Main Methods:

  • Literature review of studies on HuR function, target mRNAs, and disease implications.

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  • Focus on cancer and chronic inflammation, with discussion of cardiovascular, neurological, and muscular pathologies.
  • Analysis of therapeutic strategies targeting HuR.

    • Main Results:

    • HuR plays a central role in cellular functions and its aberrant role in diseases is increasingly recognized.
    • HuR's involvement is well-established in cancer and chronic inflammation.
    • Emerging evidence links HuR to cardiovascular, neurological, and muscular diseases.

    Conclusions:

    • HuR is a key regulator of gene expression with significant implications in various diseases.
    • Targeting HuR therapeutically holds potential but faces challenges.
    • Further research is needed to fully understand and exploit HuR's role in human health and disease.