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The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

The Spindle Assembly Checkpoint

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Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

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Related Experiment Video

Updated: May 26, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Mitotic checkpoint control and chromatin remodeling.

Yixin Yao¹, Wei Dai

¹Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

Frontiers in Bioscience (Landmark Edition)

|December 29, 2011

Summary

Eukaryotic cells use spindle checkpoints to ensure chromosomal stability. Novel research reveals spindle checkpoint proteins, like Bub1 and Sgo1, are crucial for regulating histone modifications and chromatin remodeling.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Eukaryotic cells employ checkpoints to maintain chromosomal stability during cell division.
Spindle checkpoint ensures proper microtubule attachment to chromosomes before mitosis.
Histone modifications influence cell cycle progression.

Purpose of the Study:

To review emerging evidence on the role of spindle checkpoint proteins in chromatin remodeling.
To highlight the connection between cell division regulation and epigenetic modifications.

Main Methods:

Literature review of recent studies.
Analysis of the functions of mitotic proteins Bub1 and Sgo1.
Synthesis of information on spindle checkpoint and chromatin remodeling.

Main Results:

Spindle checkpoint proteins, including Bub1 and Sgo1, are implicated in regulating histone modifications.
These proteins play a significant role in chromatin remodeling processes.
A novel function for spindle checkpoint proteins beyond cell division control is emerging.

Conclusions:

Spindle checkpoint proteins have a newly recognized role in regulating histone modifications and chromatin remodeling.
This highlights an intricate link between cell cycle control and epigenetic regulation.
Further research into these proteins could reveal new therapeutic targets.