Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

Regulation of Bacterial Virulence

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

Global Regulatory Systems

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

Other Stress Responses in Bacteria

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eosinophils but not mast cells exert anti-tumorigenic activity, without being predictive markers of the long-term response to Bacillus Calmette-Guérin (BCG) therapy in patients with bladder carcinoma.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2025

Same author

Opportunities and challenges in the therapeutic exploitation of histamine and histamine receptor pharmacology in inflammation-driven disorders.

Pharmacology & therapeutics·2024

Same author

Carbon Nanotube-Mediated Delivery of PTEN Variants: In Vitro Antitumor Activity in Breast Cancer Cells.

Molecules (Basel, Switzerland)·2024

Same author

Infiltrating Basophils Tune Injured Skin Barrier Recovery.

The Journal of investigative dermatology·2024

Same author

Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases.

Annual review of pharmacology and toxicology·2023

Same author

Mast cells contribute to the resolution of allergic inflammation by releasing resolvin D1.

Pharmacological research·2023

Search research articles

Related Experiment Video

Updated: May 26, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Histamine in two component system-mediated bacterial signaling.

Dimitrios A Kyriakidis¹, Marina C Theodorou, Ekaterini Tiligada

¹Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Greece. kyr@chem.auth.gr

Frontiers in Bioscience (Landmark Edition)

|December 29, 2011

Summary

Histamine influences bacterial processes like poly-(R)-3-hydroxybutyrate (cPHB) synthesis and chemotaxis in E. coli, mediated by the AtoSC two-component system (TCS). This suggests novel roles for histamine in microbial physiology and host interactions.

More Related Videos

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

Microbiology
Molecular Biology
Biochemistry

Background:

Histamine is a crucial mediator in mammalian cellular processes, inflammation, and host defense against bacterial infections.
Emerging evidence suggests histamine also plays roles in eukaryotes and prokaryotes, potentially influencing bacteria-host interactions.
Two-component systems (TCSs) are vital bacterial signal transduction networks regulating adaptation and proliferation.

Purpose of the Study:

To investigate the role of exogenous histamine in bacterial physiology.
To explore the involvement of histamine in the AtoSC TCS-mediated regulation of cellular processes in Escherichia coli.
To understand the implications of histamine's bacterial functions in host-microbe interactions and therapeutic strategies.

Main Methods:

Utilized Escherichia coli as a model organism.
Investigated the impact of exogenous histamine on AtoSC TCS-regulated pathways.
Analyzed effects on poly-(R)-3-hydroxybutyrate (cPHB) biosynthesis and chemotactic behavior.

Main Results:

Exogenous histamine was found to influence AtoSC TCS-mediated poly-(R)-3-hydroxybutyrate (cPHB) biosynthesis in E. coli.
Histamine also demonstrated an impact on the chemotactic behavior of E. coli.
These findings indicate a functional role for histamine in bacterial physiology.

Conclusions:

Histamine plays a previously undefined role in bacterial physiology, impacting cPHB biosynthesis and chemotaxis via the AtoSC TCS.
The study highlights the significance of histamine in bacteria-host interactions, including symbiosis, dysbiosis, and pathogenicity.
Findings suggest potential consequences for therapies targeting histamine receptors, particularly the H4 receptor.