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Differential impact of Toll-like receptor signaling on distinct B cell subpopulations

Almut Meyer-Bahlburg1, David J Rawlings

  • 1Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, D-30625 Germany. meyer-bahlburg.almut@mh-hannover.de

Frontiers in Bioscience (Landmark Edition)
|December 29, 2011
PubMed

B cells exhibit a range of functional responses following TLR engagement including immunoglobulin and cytokine production, proliferation, antigen presentation and migration. However, B cell intrinsic TLR responses appear to be precisely programmed based upon the developmental stage of the cell. B cell subpopulations classified as innate immune cells including marginal zone and B-1 B cells exhibit robust responses to TLR stimulation. In contrast, activation of other B cell subsets is constrained via a variety of developmentally regulated events. In this review we provide an overview of TLR responses in murine and human B cells and specifically highlight patterns of TLR expression and developmentally regulated functional responses.

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