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Related Experiment Video

Updated: May 26, 2026

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

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Natural suppressor cells; past, present and future.

Parvin Forghani¹, M R Khorramizadeh, Edmund K Waller

¹School of Public Health, Dept of Medical Biotechnology, School of Advanced Medical Technologies Tehran University of Medical Sciences, Tehran, Iran.

Frontiers in Bioscience (Elite Edition)

|December 29, 2011

Summary

Myeloid Derived Suppressor Cells (MDSCs) are immune cells that suppress immune responses. These cells are found in cancer patients and can be a therapeutic target for cancer treatment.

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Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Area of Science:

Immunology
Oncology
Cell Biology

Background:

Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of myeloid cells.
MDSCs exhibit potent immune suppressive activity.
These cells are implicated in tumor progression and immune evasion.

Purpose of the Study:

To define the role of MDSCs in cancer immunity.
To explore MDSCs as a potential therapeutic target for cancer treatment.

Main Methods:

Review of existing literature on MDSCs in cancer.
Analysis of MDSC infiltration in tumor-bearing models and cancer patients.

Main Results:

MDSCs accumulate in various tissues, including bone marrow, spleen, and peripheral blood, in tumor-bearing hosts.
MDSC accumulation is also observed in non-tumor bearing hosts under conditions like infection, chemotherapy, stress, and immune senescence.
MDSCs are identified as key regulators of immune responses, contributing to tumor-associated immune defects.

Conclusions:

MDSCs play a critical role in suppressing anti-tumor immunity.
Targeting MDSCs represents a promising therapeutic strategy for enhancing anti-cancer immune responses.