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Curcumin: the multi-targeted therapy for cancer regression.
Dewan Md Sakib Hossain1, Sankar Bhattacharyya, Tanya Das
1Division of Molecular Medicine, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, India.
Frontiers in Bioscience (Scholar Edition)
|December 29, 2011
Summary
Curcumin, a natural polyphenol, exhibits diverse anti-cancer properties, including anti-carcinogenic and antioxidant effects. This review explores its molecular mechanisms for potential clinical cancer prevention strategies.
Area of Science:
- Oncology
- Molecular Biology
- Natural Product Chemistry
Background:
- Cancer involves complex genetic and signaling pathway deregulation.
- Current cancer therapies have adverse effects, necessitating safer alternatives.
- Natural compounds like curcumin offer multi-targeted therapeutic potential.
Purpose of the Study:
- To review the anti-cancer properties of curcumin.
- To emphasize the molecular basis of curcumin's action in tumorigenesis.
- To explore curcumin's potential for clinical cancer prevention.
Main Methods:
- Literature review focusing on molecular mechanisms of curcumin's anti-cancer activities.
- Analysis of curcumin's effects on cell signaling pathways.
- Evaluation of curcumin's antioxidant and systemic toxicity amelioration.
Main Results:
- Curcumin demonstrates anti-carcinogenic, pro-apoptotic, anti-angiogenic, anti-metastatic, immunomodulatory, and antioxidant activities.
- Its pleotropic effects involve diverse molecular mechanisms and cell signaling pathways.
- Curcumin acts as a potent reactive oxygen species scavenger, reducing tumor-bearer toxicity.
Conclusions:
- Curcumin possesses significant anti-cancer properties with broad molecular targeting capabilities.
- Its safety profile and multifaceted actions make it a promising candidate for cancer prevention.
- Further clinical investigation into curcumin's therapeutic potential is warranted.
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