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The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
TGF-beta antiproliferative effects in tumor suppression
Stephan Christopher Jahn1, Mary Elizabeth Law, Patrick Evan Corsino
1Department of Pharmacology and Therapeutics, Shands Cancer Center, University of Florida, Gainesville, FL 32610, United States.
Frontiers in Bioscience (Scholar Edition)
|December 29, 2011
Summary
The transforming growth factor-beta (TGF-beta)/Smad signaling pathway exhibits tumor-suppressive functions in cancer. This review compiles evidence from various studies to support this role and considers therapeutic strategies targeting TGF-beta.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Signaling
Background:
- The transforming growth factor-beta (TGF-beta) signaling pathway plays a dual role in cancer, with some functions suppressing tumor formation and others promoting progression.
- The TGF-beta/Smad signaling axis is a key component of this pathway, influencing various cellular processes relevant to cancer.
Purpose of the Study:
- To present evidence supporting a tumor-suppressive role for the TGF-beta/Smad signaling axis.
- To explore therapeutic strategies for cancer treatment that modulate TGF-beta pathway activities.
Main Methods:
- Compilation of data from cell culture studies.
- Analysis of animal models of cancer.
- Examination of human tumor samples.
- Investigation of genetic polymorphisms in TGF-beta pathway components and their association with cancer risk.
Main Results:
- Evidence from multiple research avenues supports a tumor-suppressive role for the TGF-beta/Smad pathway.
- Polymorphisms in TGF-beta pathway components are linked to cancer risk, further underscoring the pathway's significance.
Conclusions:
- The TGF-beta/Smad signaling axis demonstrates significant tumor-suppressive activities.
- Therapeutic strategies could involve enhancing TGF-beta's tumor-suppressive functions or inhibiting its pro-tumorigenic roles in cancer treatment.
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