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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

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Related Experiment Video

Updated: May 26, 2026

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

Finding cancer's weakest link.

Nicole M Sodir1, Gerard I Evan

  • 1Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.

Oncotarget
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

Myc is a crucial protein for cell proliferation that cancer cells cannot compensate for when targeted. This makes Myc an ideal target for novel cancer drug development, offering a promising therapeutic strategy.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Systems Biology

Background:

  • Vertebrate biological systems possess inherent robustness and adaptability to maintain homeostasis.
  • Cancer cells are mechanistically diverse and can evolve resistance to therapies.
  • Identifying non-redundant targets is crucial for effective cancer drug development.

Purpose of the Study:

  • To review the role of Myc in coordinating cellular programs essential for proliferation.
  • To evaluate Myc as a potential cancer drug target due to its unique properties.

Main Methods:

  • Literature review of Myc's function in cell proliferation.
  • Analysis of Myc's role in cancer cell survival and adaptation.
  • Discussion of in vivo genetic data supporting Myc as a drug target.

Main Results:

  • Myc plays a unique, non-degenerate, and pleiotropic role in coordinating proliferation programs.
  • Myc's function is essential for cancer cell survival in vivo.
  • Myc's critical role makes it difficult for cancer cells to compensate for its inhibition.

Conclusions:

  • Myc's essential and non-redundant functions present it as a compelling cancer drug target.
  • Targeting Myc could overcome cancer cell adaptive resistance mechanisms.
  • Recent in vivo data reinforce Myc's potential as a therapeutic target in oncology.