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Relation between thyroid and cardiac functions and the geriatric rating scale.
A Ichibangase1, M Nishikawa, T Iwasaka
1Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Acta Neurologica Scandinavica
|June 1, 1990
Summary
Thyroid hormone levels and cardiac function impact cognitive decline in older adults. Lower thyroid hormone (free T3) and cardiac index are linked to cerebrovascular dementia, suggesting they indicate cognitive health.
Area of Science:
- Gerontology
- Neurology
- Endocrinology
Background:
- Senile dementia is a growing concern in aging populations.
- Thyroid hormone and cardiac function are vital for overall health and cognition.
- The interplay between these factors in dementia pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the relationship between thyroid hormone levels, cardiac function, and cognitive status in individuals aged 70 and above.
- To differentiate the impact of thyroid hormone and cardiac function in various types of dementia.
Main Methods:
- Studied 83 subjects aged 70+.
- Measured serum thyroid hormone concentrations (specifically free T3).
- Assessed hemodynamic parameters (cardiac index) and dementia severity using rating scales.
Main Results:
- A negative correlation was observed between age and serum-free T3 concentrations.
- Individuals with cerebrovascular dementia exhibited significantly lower serum-free T3 and cardiac index compared to those without dementia.
- Patients with cerebrovascular dementia showed lower serum-free T3 and cardiac index than those with Alzheimer's type dementia.
Conclusions:
- Cognitive function, particularly in cerebrovascular dementia, is closely associated with serum free T3 levels and cardiac function.
- Serum free T3 concentrations may serve as a valuable biomarker for cognitive status and overall health in the elderly.