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Related Experiment Videos

Abnormal hemorheological parameters in vertebrobasilar-insufficiency.

K H Grotemeyer1

  • 1Department of Neurology, University of Münster, West Germany.

Acta Neurologica Scandinavica
|June 1, 1990
PubMed
Summary

Vertebrobasilar insufficiency (VBI) patients often exhibit abnormal hemorheological findings, including high platelet reactivity and plasma viscosity. These blood flow measurements may aid in diagnosing VBI symptoms like headache and vertigo.

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Area of Science:

  • Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Vertebrobasilar insufficiency (VBI) is a condition affecting blood flow to the brain.
  • Hemorheological factors, or blood flow properties, are increasingly recognized for their role in cerebrovascular diseases.
  • Understanding hemorheological profiles in VBI patients is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate hemorheological parameters in patients diagnosed with VBI.
  • To determine the prevalence of specific hemorheological abnormalities in this patient group.
  • To assess the potential utility of hemorheological testing in clarifying VBI-related symptoms.

Main Methods:

  • Hemorheological examination of 37 patients diagnosed with VBI (mean age 47 years).

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  • Assessment included platelet-reactivity, plasma-viscosity, fibrinogen levels, red-blood-cell-aggregation, and hematocrit.
  • Comparison of hemorheological findings with those typically observed in stroke and TIA patients.

    • Main Results:

    • All VBI patients exhibited some abnormal hemorheological findings, even those without traditional vascular risk factors.
    • Abnormalities were most frequent in platelet-reactivity (78%) and plasma-viscosity (57%).
    • Other notable findings included elevated fibrinogen (23%), red-blood-cell-aggregation (13%), and hematocrit (11%).

    Conclusions:

    • Hemorheological parameters are consistently altered in patients with VBI.
    • Platelet-reactivity and plasma-viscosity are key indicators of hemorheological disturbance in VBI.
    • Incorporating hemorheological assessments, such as platelet-reactivity and plasma-viscosity, may improve the diagnostic workup for VBI symptoms like headache and vertigo.