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Intercellular adhesion molecule 1 gene K469E polymorphism is associated with coronary heart disease risk: a

Ya-Nan Ji1, Qin Wang, Ping Zhan

  • 1Jiangsu Province Hospital of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, China.

Molecular Biology Reports
|December 29, 2011
PubMed

Insights

The ICAM1 gene K469E polymorphism is linked to increased coronary heart disease (CHD) risk. Specifically, the K allele is a significant risk factor for CHD in Asian and Caucasian populations.

Area of Science:

  • Genetics and Cardiovascular Disease Research
  • Molecular Biology and Epidemiology

Background:

  • Coronary atherosclerosis is a primary cause of coronary heart disease (CHD).
  • Atherosclerotic lesions result from complex polygenic interactions influenced by environmental factors.
  • Previous studies on the association between the ICAM1 gene E469K polymorphism and CHD have yielded conflicting results.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis to clarify the association between the ICAM1 gene E469K polymorphism and coronary heart disease (CHD).

Main Methods:

  • A comprehensive search of PubMed, Embase, and CNKI databases was performed for relevant case-control studies published up to August 2011.
  • Data from twelve eligible studies, including 2,157 cases and 1,952 controls, were extracted and analyzed.
  • Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association.

Main Results:

  • The meta-analysis revealed a significant association between the ICAM1 gene E469K polymorphism and an increased risk of CHD.
  • The K allele demonstrated a higher risk (OR = 1.496, 95% CI = 1.363-1.642) compared to the E allele.
  • Carriers of the K allele showed a significantly increased risk (OR = 1.919, 95% CI = 1.635-2.253) compared to individuals with the EE genotype.

Conclusions:

  • The ICAM1 gene K469E polymorphism is significantly associated with the risk of coronary heart disease (CHD).
  • The K allele of the ICAM1 gene represents a notable risk factor for developing CHD, particularly in Asian and Caucasian populations.

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