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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
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NCCN molecular testing white paper: effectiveness, efficiency, and reimbursement.

Paul F Engstrom, Mara G Bloom, George Daniel Demetri

    Journal of the National Comprehensive Cancer Network : JNCCN
    |December 29, 2011
    PubMed
    Summary

    Personalized medicine in oncology relies on molecular testing. Challenges in healthcare provider knowledge, clinical utility, and test validity need addressing for safe and effective cancer care.

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    Published on: April 11, 2016

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    Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

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    Area of Science:

    • Oncology
    • Molecular Diagnostics
    • Personalized Medicine

    Background:

    • The rapid evolution of personalized medicine in oncology necessitates robust molecular testing strategies.
    • Increasing reliance on molecular biomarkers for clinical decisions highlights the need for safe and effective test deployment.

    Framework:

    • The National Comprehensive Cancer Network (NCCN) convened a Molecular Testing Work Group in May 2011.
    • The work group comprised thought leaders to address challenges and provide guidance on molecular testing in oncology.

    Implementation:

    • Key challenges identified include healthcare provider education on molecular tests.
    • Determining the clinical utility and ensuring the analytic and clinical validity of molecular tests are critical.
    • Efficient specimen utilization and establishing clear coding and billing practices are essential.

    Implications:

    • Addressing these challenges is crucial for the appropriate use of molecular tests in guiding cancer care.
    • Developing clinical evidence is vital for validating the utility of molecular diagnostics.
    • Improved molecular testing frameworks will enhance the safe, effective, and efficient delivery of personalized oncology treatments.