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Published on: February 28, 2020
Warthin tumor--morphological study of the stromal compartment
Luminiţa Dăguci1, Cristiana Simionescu, A Stepan
1Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
Summary
Warthin tumor, a common parotid gland neoplasm, shows increasing incidence in older males. Immunohistochemical analysis reveals lymphocyte markers (CD20, CD45RO) present in both tumor components, resembling reactive lymph nodes.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Warthin tumor is the second most frequent benign parotid gland neoplasm, following pleomorphic adenoma.
- Understanding the cellular composition and immune markers of Warthin tumors is crucial for diagnosis and research.
Purpose of the Study:
- To analyze the clinical, histological, and immunohistochemical features of Warthin tumors.
- To investigate the expression of CD20 and CD45RO in Warthin tumor components.
Main Methods:
- Clinical data from 21 Warthin tumor cases diagnosed between 2005-2010 were reviewed.
- Histopathological analysis assessed the stroma-to-parenchyma ratio.
- Immunohistochemistry utilized anti-CD20 and anti-CD45RO antibodies.
Main Results:
- Warthin tumor incidence increases in the seventh decade of life, predominantly affecting males (M/F ratio 5:2).
- Histopathology showed a balanced stroma-parenchyma distribution in most cases (14/21).
- Immunohistochemistry revealed CD20 and CD45RO positivity in both epithelial and stromal components, with patterns similar to reactive lymph nodes.
Conclusions:
- Warthin tumors exhibit distinct demographic trends, with a notable rise in incidence among older males.
- The presence and distribution of lymphoid markers (CD20, CD45RO) suggest an immune-mediated component within Warthin tumors.
- Immunohistochemical findings support a resemblance between the lymphoid stroma of Warthin tumors and that of normal or reactive lymph nodes.
