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Published on: May 17, 2024
Periarticular diffuse neurofibroma of the upper limb
Rodica Trăistaru1, Otilia Rogoveanu, Roxana Popescu
1Department of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania.
Summary
Diffuse neurofibromas are rare tumors, often affecting the trunk or limbs. This case highlights a giant diffuse neurofibroma in the shoulder girdle causing severe limb dysfunction despite surgical attempts.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Diffuse neurofibromas are uncommon, often presenting in young adults.
- They typically affect the trunk, head, neck, or limbs.
- Malignant transformation is rare, but complete surgical resection can be challenging due to infiltrative growth.
Observation:
- A rare case of a giant diffuse neurofibroma involving the left brachial plexus in an adult patient without neurofibromatosis type 1 (NF1).
- The tumor exhibited a diffuse growth pattern and plexiform architecture.
- Imaging (MRI, sonography) and histopathology confirmed the diagnosis.
Findings:
- The diffuse neurofibroma caused severe functional impairment of the left upper limb.
- Despite two surgical interventions, complete resection was not achieved due to the extensive nature of the lesion.
- The patient's immediate survival was not compromised.
Implications:
- This case underscores the rarity of diffuse neurofibromas in the shoulder girdle and their potential for significant morbidity.
- Challenges in surgical management of extensive, infiltrative lesions are highlighted.
- Further research into imaging and treatment strategies for these rare tumors is warranted.
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