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Related Experiment Videos

Giant cell fibroblastoma. A case report.

T Hirose1, M Sasaki, M Shintaku

  • 1First Department of Pathology, University of Tokushima School of Medicine, Japan.

Acta Pathologica Japonica
|July 1, 1990
PubMed
Summary

Giant cell fibroblastoma is a rare fibrous tumor. This case report details a pediatric knee tumor, emphasizing its unique histological features and the importance of distinguishing it from sarcomas.

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Area of Science:

  • Pathology
  • Pediatric Oncology
  • Dermatopathology

Background:

  • Giant cell fibroblastoma (GCF) is a rare, benign soft tissue tumor.
  • It typically affects children and young adults, often presenting as a slow-growing mass.
  • Accurate diagnosis is crucial to differentiate GCF from malignant soft tissue neoplasms.

Observation:

  • A case of GCF in the knee of a 16-month-old girl is presented.
  • The tumor was a 2 x 2 cm subcutaneous lesion with an ill-defined border.
  • Histological examination revealed spindle-shaped tumor cells, atypical multinucleated giant cells (including floret-type and osteoclast-like), a myxoid/collagenous background, and sinusoid-like spaces.
  • Tumor cells showed focal storiform patterns.

Findings:

  • Immunohistochemistry demonstrated that tumor cells expressed vimentin and actin.

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  • The tumor exhibited characteristic histological features of GCF, including giant cells and specific architectural patterns.
  • Despite a known high recurrence rate for this tumor type, the patient had an uneventful post-excision course.

    • Implications:

    • This case highlights the importance of recognizing the distinct histological features of GCF.
    • Distinguishing GCF from other soft tissue tumors, particularly sarcomas, is critical for appropriate patient management.
    • Early and accurate diagnosis can lead to favorable outcomes, even with tumors known for recurrence.