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Updated: May 26, 2026

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion
Published on: December 13, 2024
An estimation method of the clearance for a one-compartment model of a single bolus intravenous injection by a single
Takashi Funatogawa1, Ikuko Funatogawa
1Vanderbilt-Ingram Cancer Center, Cancer Biostatistics Center, Nashville, Tennessee 37232-6838, USA. i-funatogawa@umin.ac.jp
Abstract:
In clinical trials, sometimes only a single drug concentration can be measured from a patient, because of the burden on the patient. From a single concentration, we cannot generally obtain point estimates of each pharmacokinetic parameter in a patient. In this article, we propose a method to estimate the clearance using a one-compartment model of a single-bolus intravenous injection from a single concentration at a sampling point between 1.5 and 2.5 half-lives. This method requires an assumed value for the volume of distribution but is robust to misspecification. This approach is illustrated by simulated concentration data and cadralazine concentration data.
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