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Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Physiological Barriers01:25

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

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Related Experiment Video

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Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
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Brainpeps: the blood-brain barrier peptide database.

Sylvia Van Dorpe1, Antoon Bronselaer, Joachim Nielandt

  • 1Drug Quality and Registration Group, Faculty of Pharmaceutical Sciences, Ghent University, Belgium.

Brain Structure & Function
|December 30, 2011
PubMed
Summary

A new database, Brainpeps, consolidates scattered blood-brain barrier (BBB) peptide transport data. This resource aids in selecting peptides for BBB studies and understanding structure-property relationships.

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Last Updated: May 26, 2026

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
06:35

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue

Published on: September 12, 2018

Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport
16:26

Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport

Published on: June 28, 2014

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
07:52

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biotechnology

Background:

  • Peptides can cross the blood-brain barrier (BBB), offering therapeutic and diagnostic potential.
  • Existing BBB transport data for peptides are fragmented across disciplines and methodologies.
  • Inconsistent reporting of influx and efflux data hinders comprehensive analysis.

Purpose of the Study:

  • To create a centralized database (Brainpeps) for blood-brain barrier (BBB) peptide transport data.
  • To consolidate both positive and negative experimental results for peptide BBB interactions.
  • To facilitate the evaluation of peptides for BBB applications and quantitative structure-property relationship studies.

Main Methods:

  • Systematic collection of published peptide BBB transport data.
  • Classification and categorization of diverse methodologies used to assess BBB behavior.
  • Analysis and visualization of interrelationships between different BBB transport assessment methods.

Main Results:

  • The Brainpeps database now contains a comprehensive collection of peptide BBB transport information.
  • A structured classification of BBB assessment methods and their outcomes has been established.
  • Visualizations clarify the relationships and concordance between various BBB transport assays.

Conclusions:

  • Brainpeps serves as a valuable resource for researchers studying peptide transport across the blood-brain barrier (BBB).
  • The database aids in prioritizing peptides and understanding their BBB behavior through quantitative structure-property relationships.
  • Standardizing and visualizing BBB transport data enhances research efficiency and comparability.