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Updated: May 26, 2026

DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
Published on: July 22, 2022
Ketamine as a novel antidepressant: from synapse to behavior
1Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. james.murrough@mssm.edu
Abstract:
Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.
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