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04:56
Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
Emergence of ceftriaxone resistant Shigella.
Neeraj Goel1, Chand Wattal, Dinesh Kaul
1Department of Clinical Microbiology and Immunology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India.
Indian Journal of Pediatrics
|December 30, 2011
Summary
Multi-drug resistant Shigella flexneri is a growing concern. A rare case of ceftriaxone-resistant Shigella flexneri was successfully treated with meropenem, highlighting potential treatment failures.
Area of Science:
- Infectious Diseases
- Microbiology
- Antimicrobial Resistance
Background:
- Shigellosis is a significant public health issue in resource-limited settings, characterized by high morbidity and mortality.
- The emergence of multi-drug resistant (MDR) Shigella species compromises the efficacy of first-line antibiotics, including quinolones, co-trimoxazole, and ampicillin.
- Ceftriaxone is often reserved for treating MDR Shigella infections.
Observation:
- This report details a case of Shigella flexneri infection resistant to ceftriaxone.
- The patient was successfully treated with meropenem, an alternative antibiotic.
Findings:
- The study documents a rare instance of ceftriaxone-resistant Shigella flexneri.
- Successful management of this resistant strain was achieved using meropenem.
Implications:
- This case underscores the potential for ceftriaxone treatment failure in shigellosis.
- Timely detection of antibiotic resistance is crucial to prevent mortality associated with shigellosis.
- The findings emphasize the need for ongoing surveillance of antimicrobial resistance patterns in Shigella species.
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