Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of Lung Injury Biomarkers in Patients Hospitalized With COVID-19 Without Respiratory Failure at Admission.

Critical care medicine·2026
Same author

Can Influenza virus cause bacteremia, sepsis, and septic shock?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Two case reports on the identification and management of hypervirulent <i>Klebsiella pneumoniae</i> isolated in Nebraska, USA.

ASM case reports·2026
Same author

In sepsis, a tailored precision immunotherapy strategy improved organ function at 9 d.

Annals of internal medicine·2026
Same author

Inhaled Antibiotics for Ventilator-Associated Pneumonia: Is It Ready for Prime Time?

Critical care medicine·2026
Same author

Advancing the Prevention of Surgical Site Infections Through Antibiotic Prophylaxis.

Anaesthesia, critical care & pain medicine·2026

Related Experiment Video

Updated: May 26, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Pediococcus acidilactici endocarditis successfully treated with daptomycin.

Peter C Iwen1, Cezarina Mindru, Andre C Kalil

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA. piwen@unmc.edu

Journal of Clinical Microbiology
|December 30, 2011
PubMed
Summary
This summary is machine-generated.

Persistent bacteremia and endocarditis caused by Pediococcus acidilactici, a rare occurrence, was identified in a patient with short gut syndrome. Species identification via intergenic spacer region sequencing and successful treatment with daptomycin were highlighted.

Related Experiment Videos

Last Updated: May 26, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Transplant Surgery

Background:

  • Endocarditis is a serious infection of the heart valves, often caused by bacteria.
  • Pediococcus species are typically found in fermented foods and rarely cause human infections.
  • Short gut syndrome can lead to complications, including increased risk of infections.

Observation:

  • A 32-year-old male with short gut syndrome post-small bowel transplant developed persistent bacteremia.
  • The patient presented with clinical signs suggestive of endocarditis.

Findings:

  • The causative agent was identified as Pediococcus acidilactici, marking the first reported case of endocarditis due to this organism.
  • Sequencing of the intergenic spacer region proved effective for accurate species identification.
  • Treatment with daptomycin resulted in successful eradication of the bacteria and resolution of the infection.

Implications:

  • This case expands the spectrum of pathogens causing endocarditis, including rare organisms like Pediococcus acidilactici.
  • Highlights the importance of advanced molecular techniques like sequencing for identifying unusual pathogens.
  • Suggests daptomycin as a potential therapeutic option for Pediococcus acidilactici infections, particularly in complex patient cases.