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CD93: recent advances and implications in disease

Mallary C Greenlee-Wacker1, Manuel D Galvan, Suzanne S Bohlson

  • 1Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.

Current Drug Targets
|December 31, 2011
PubMed

Insights

The C1q/MBL/collectin/ficolin family member CD93 (also known as AA4.1 or decorin proteoglycan 2) is crucial for innate immunity and inflammation. Recent studies reveal its role in disease progression, offering new insights into its molecular function.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • CD93 (C1q/MBL/collectin/ficolin family) is known to regulate innate immunity and inflammation.
  • Its specific role in disease progression is an emerging area of research.
  • Recent in vivo and genome-wide studies provide new functional insights.

Purpose of the Study:

  • To review CD93 expression patterns.
  • To focus on recent findings (last three years) regarding CD93's function in inflammation and innate immunity.
  • To elucidate the putative molecular function of CD93 in disease.

Main Methods:

  • Comprehensive review of existing literature.
  • Analysis of recent in vivo studies in mice.
  • Examination of genome-wide association studies in mice and humans.

Main Results:

  • CD93 expression patterns are detailed.
  • Recent findings on CD93's role in inflammation and innate immunity are highlighted.
  • Molecular functions of CD93 in disease progression are discussed.

Conclusions:

  • CD93 plays a significant role in innate immunity and inflammation.
  • Emerging evidence points to CD93's involvement in disease progression.
  • Further research is needed to fully understand CD93's molecular mechanisms.

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