Related Experiment Video
Updated: May 26, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
[Vitamin D and autoimmunity. First part: Fundamental aspects]
Y Schoindre1, B Terrier, J-E Kahn
1Service de médecine interne, université Versailles Saint-Quentin-en-Yvelines, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France. y.schoindre@hopital-foch.org
La Revue De Medecine Interne
|December 31, 2011
Summary
Vitamin D impacts bone health and immunity. Emerging research highlights its crucial role in immune cell function and fighting inflammation, suggesting broader health benefits beyond bone metabolism.
Area of Science:
- Endocrinology
- Immunology
- Cell Biology
Context:
- Vitamin D's established role in calcium homeostasis and bone metabolism is widely recognized.
- Suboptimal vitamin D levels are a global health concern, reaching pandemic proportions.
- Recent research increasingly highlights vitamin D's significant extra-skeletal functions, particularly its influence on the immune system.
Purpose:
- To investigate the multifaceted effects of vitamin D on various immune components.
- To explore vitamin D's influence on cellular processes like antimicrobial peptide synthesis and autophagy.
- To assess the potential therapeutic applications of vitamin D in autoimmune and inflammatory conditions.
Summary:
- This study examines vitamin D's actions on key immune cells, including myeloid dendritic cells, T cells, and B cells.
- The research details vitamin D's role in modulating the synthesis of antimicrobial peptides and influencing autophagy.
- Findings suggest vitamin D plays a vital role in immune regulation and may offer benefits for autoimmune and inflammatory diseases.
Impact:
- Provides a comprehensive overview of vitamin D's immunomodulatory effects.
- Highlights vitamin D's potential as a therapeutic agent for immune-related disorders.
- Underscores the importance of maintaining adequate vitamin D status for overall health and immune function.
Related Concept Videos
01:23Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:12Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:22Connective Tissue Cell Types
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...