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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Related Experiment Video

Updated: May 26, 2026

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil
06:48

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Published on: July 29, 2020

Differences in dietary pattern between obese and eutrophic children.

Emilia A Balthazar1, Maria R M de Oliveira

  • 1Food and Nutrition Department, School of Pharmaceutical Sciences at the São Paulo State University, road Araraquara-Jau km1, CP 502, 14801-902 Araraquara, SP, Brasil.

BMC Research Notes
|December 31, 2011
PubMed
Summary
This summary is machine-generated.

Childhood obesity is linked to low dietary fiber intake, not just excess calories. Obese children consumed significantly less fiber, particularly from beans and vegetables, compared to their healthy-weight peers.

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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Assessment of Child Anthropometry in a Large Epidemiologic Study

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Last Updated: May 26, 2026

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil
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Published on: July 29, 2020

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

  • Pediatric Nutrition
  • Obesity Research
  • Dietary Pattern Analysis

Background:

  • Excessive energy intake is a primary driver of obesity.
  • Quantitative energy assessment alone may not fully explain obesity, highlighting the need to consider dietary quality.

Purpose of the Study:

  • To investigate differences in nutrient composition and meal patterns between eutrophic and obese schoolchildren.
  • To assess the role of qualitative dietary factors in childhood obesity.

Main Methods:

  • Dietary recalls were used to assess the intake of 83 children (7-11 years old), divided into obese and eutrophic groups.
  • Software analysis quantified macronutrients and micronutrients.
  • Consumption patterns of legumes, fruits, and vegetables were analyzed to determine dietary patterns.

Main Results:

  • No significant differences in total energy consumption were found between obese and eutrophic children.
  • Eutrophic children consumed more dietary fiber (20.7g) than obese children (14.8g).
  • Higher fiber intake, especially from beans, correlated with lower dietary fat proportion and was linked to healthier weight status.

Conclusions:

  • Childhood obesity in this cohort was associated with a dietary pattern characterized by low fiber intake.
  • Dietary fiber, particularly from legumes and vegetables, plays a crucial role in weight management.
  • Qualitative aspects of diet, such as fiber content, are more critical than solely energy intake in childhood obesity.