Related Experiment Video
Updated: May 26, 2026

Methodology to Metabolically Inactivate Bacteria for Caenorhabditis elegans Research
Published on: July 28, 2023
Why do we worship P < .05?
Duncan Neuhauser1, Lloyd Provost
1Department of Epidemiology and Biostatistics, Medical School, Case Western Reserve University, Cleveland, Ohio 44106, USA. dvn@case.edu
Abstract:
The headlines shout "medical breakthrough." The study results are significant. Regulatory approval, billions of dollars in drug sales, publications in high-impact journals, promotions, tenure and fame, all because P < .05. How did the P value get to play such a prominent role in how medicine is practiced?
More Related Videos
Related Concept Videos
P-value
P-value stands for the probability value. P-value is the probability that, if the null hypothesis is true, the results from another randomly selected sample will be as extreme or more extreme as the results obtained from the given sample.
A large P-value calculated from the data indicates to not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more unlikely...
Decision Making: P-value Method
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Testing a Claim about Population Proportion
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
Bonferroni Test
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...
Identifying Statistically Significant Differences: The F-Test
Fisher's Exact Test

