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Updated: May 26, 2026

Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
Published on: January 14, 2021
[Regulation of gene expression during spermatogenesis at transcriptional level]
Xiu-Jun Zhang1, Mei-Ling Liu, Meng-Chun Jia
1National Research Institute for Family Planning, Beijing, China. zhangxiujun66@yahoo.com.cn
Abstract:
Mammalian spermatogenesis is a highly complex cell division and differentiation process occurring in the seminiferous tubules of the testis. This processes are regulated at both transcriptional and post-transcriptional levels, any mistake in this process can lead to infertility. Unveiling the molecular mechanisms of spermatogenesis has important implications for exploring novel contraceptive approach and treatment of infertility. This review addresses recent progress towards understanding the regulation of androgen, estrogen and their receptors, transcription factors and chromatin-associated factors for spermatogenesis at transcriptional level.
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