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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Low grade sinonasal adenocarcinoma]
Ayşe Tülay Sayilgan1, Gülçin Kamali, Deniz Ozcan
1S. B. Okmeydanı Eğitim ve Araştırma Hastanesi, Patoloji Bölümü, İstanbul, Türkiye. tulaysay@gmail.com
Turk Patoloji Dergisi
|December 31, 2011
Summary
This study presents a rare case of low-grade, nonintestinal sinonasal adenocarcinoma in an oil painter. The classification of sinonasal adenocarcinoma is crucial for predicting patient prognosis.
Area of Science:
- Oncology
- Pathology
Background:
- Sinonasal adenocarcinoma, a rare cancer, is categorized into intestinal or nonintestinal types based on histological resemblance to gastrointestinal mucosa.
- These tumors are linked to occupational and environmental carcinogen exposure.
Observation:
- A case of a 50-year-old male oil painter with low-grade, nonintestinal sinonasal adenocarcinoma originating in the left middle concha and ethmoid sinus is detailed.
- Microscopic examination revealed infiltrative glandular structures with cystic dilation, papillary formations, and a cribriform pattern.
- Immunohistochemical analysis showed tumor cells positive for CK7, focally positive for CK20, and negative for CDX2, consistent with a nonintestinal type.
Findings:
- The tumor exhibited features of a low-grade nonintestinal type, with specific immunohistochemical markers supporting this classification.
- Negative results for S-100, Actin, p63, TTF-1, and p53, along with a low Ki-67 index (2%), further characterized the tumor.
- The distinction between intestinal and nonintestinal types is significant, as intestinal types are typically high-grade, while nonintestinal types are generally low-grade.
Implications:
- Morphological and immunohistochemical classification aids in predicting the prognosis of sinonasal adenocarcinoma.
- Integrating clinical information with pathological findings is essential for differentiating sinonasal adenocarcinoma from other lesions.
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