Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PRISM-Gen: A physics-informed multi-fidelity framework for broad-spectrum coronavirus mpro inhibitor discovery.

Computational biology and chemistry·2026
Same author

Structural composition and functional diversities of G proteins in fungi.

Mycology·2026
Same author

Integrated transcriptomic profiling of programmed cell death patterns unveils macrophage-hepatocyte crosstalk via THBS1-CD47 axis in hepatic ischemia-reperfusion injury.

Frontiers in immunology·2026
Same author

Integrating network annotation from multiple correlated traits to improve polygenic risk scores based on GWAS summary statistics.

Research square·2026
Same author

Extreme heat and hospitalization with Parkinson's disease among older adults.

Journal of exposure science & environmental epidemiology·2026
Same author

Clinical risk factors and predictive value of inflammatory biomarkers for 2-year recurrence after standard surgery for endometrial cancer: a retrospective study among the Chinese population.

Future oncology (London, England)·2026

Related Experiment Video

Updated: May 26, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Pregnancy in multiple system atrophy: a case report.

Lirong Zhu1, Nigel J Cairns, Samer D Tabbal

  • 1Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA. racetteb@neuro.wustl.edu.

Journal of Medical Case Reports
|January 3, 2012
PubMed
Summary
This summary is machine-generated.

Pregnancy may accelerate multiple system atrophy (MSA) progression in women of child-bearing age. This α-synucleinopathy, often mistaken for Parkinson's disease early on, requires further study regarding its course during gestation.

More Related Videos

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Related Experiment Videos

Last Updated: May 26, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Area of Science:

  • Neuroscience
  • Neuropathology
  • Clinical Neurology

Background:

  • Multiple system atrophy (MSA) is an adult-onset α-synucleinopathy.
  • The impact of pregnancy on MSA disease course is largely unknown.
  • Early MSA can be misdiagnosed as Parkinson's disease.

Purpose of the Study:

  • To describe the clinical course and neuropathological findings of a patient with multiple system atrophy (MSA) who experienced pregnancy.
  • To investigate the potential influence of pregnancy on the progression of MSA.

Main Methods:

  • Case report of an Irish woman diagnosed with parkinsonism at age 31.
  • Detailed description of her pregnancy, complications (orthostatic hypotension, motor fluctuations), and subsequent treatments (deep brain stimulation).
  • Post-mortem neuropathological examination confirming striatonigral degeneration and α-synuclein pathology consistent with MSA.

Main Results:

  • The patient experienced severe orthostatic hypotension and motor fluctuations during pregnancy.
  • Despite subthalamic nuclei deep brain stimulation, motor symptoms deteriorated post-partum.
  • Neuropathology confirmed MSA, indicating the disease affected a woman of child-bearing age.

Conclusions:

  • Multiple system atrophy (MSA) can affect women of reproductive age.
  • Pregnancy may be associated with accelerated disease progression in MSA patients.
  • Further research is needed to understand MSA in pregnant women.