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Updated: May 26, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

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Intraventricular twin fetuses in fetu.

Lauren N Huddle¹, Christine Fuller, Tiffany Powell

¹Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia 23298-0662, USA. lhuddle@mcvh-vcu.edu

Journal of Neurosurgery. Pediatrics

|January 3, 2012

Summary

This report details a rare case of intracranial fetuses in fetu, a parasitic twin condition. Genetic analysis confirmed the fetuses were genetically identical to the host, supporting a monozygotic twin origin.

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Published on: October 9, 2018

Area of Science:

Developmental Biology
Medical Genetics
Neurology

Background:

Fetus in fetu is a rare congenital anomaly where one twin is enclosed within the body of the other.
Intracranial fetuses in fetu is exceptionally rare, with few documented cases.

Observation:

A neonate presented with ventriculomegaly and intracranial calcifications suggestive of an axial skeleton.
Imaging revealed two complex intraventricular masses containing skeletal and soft tissue elements.
Surgical resection at 3 months of age confirmed the presence of fetuses in fetu with well-developed structures.

Findings:

The intracranial masses exhibited axial and appendicular skeletons, skin, hair, muscle, bone marrow, and multiple viscera.
Genetic analysis, including single nucleotide polymorphism array, demonstrated that the fetuses in fetu were genetically identical to the host infant.
This confirms a monozygotic twin embryonic origin for this rare intracranial presentation.

Implications:

This case expands the understanding of fetuses in fetu, particularly its rare intracranial intraventricular occurrence.
Genome-wide genetic analysis provides definitive evidence for monozygotic twinning as the origin.
Highlights the importance of advanced imaging and genetic testing in diagnosing and understanding complex congenital anomalies.