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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

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Related Experiment Video

Updated: May 26, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

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Prescribing cannabis for harm reduction.

Mark Collen1

  • 1PainExhibit,com, 9008 El Cajon Way, #4, Sacramento, CA, 95826, USA. Mark@PainExhibit.com.

Harm Reduction Journal
|January 3, 2012
PubMed
Summary

Neuropathic pain is common and difficult to treat. Cannabis may be a safer alternative to opioids for nerve pain, potentially reducing deaths from prescription pain medications.

Area of Science:

  • Pain Medicine
  • Pharmacology
  • Neurology

Background:

  • Neuropathic pain impacts 5-10% of the US population, often proving resistant to conventional therapies.
  • Opioids are frequently prescribed for neuropathic pain but carry significant risks, including fatal overdose.
  • Cannabis presents a potential alternative, demonstrating efficacy in managing nerve pain without lethal toxicity concerns.

Discussion:

  • The study proposes a harm reduction approach for neuropathic pain management.
  • It suggests evaluating patients for cannabis therapy before initiating or continuing opioid prescriptions.
  • This strategy aims to mitigate the severe morbidity and mortality linked to opioid analgesics.

Key Insights:

  • Cannabis offers a viable, less toxic option for neuropathic pain relief compared to opioids.

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Related Experiment Videos

Last Updated: May 26, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

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  • Physician-guided trials of cannabis can be a crucial step in safer pain management.
  • Implementing cannabis as an alternative may significantly decrease opioid-related adverse events.

    • Outlook:

    • Further clinical research is warranted to establish optimal cannabis-based treatment protocols for neuropathic pain.
    • Regulatory frameworks may need to adapt to facilitate physician and patient access to medical cannabis.
    • This approach could reshape clinical guidelines for chronic pain, prioritizing patient safety and harm reduction.