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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Maximizing tumor immunity with fractionated radiation.

Dörthe Schaue1, Josephine A Ratikan, Keisuke S Iwamoto

  • 1Department of Radiation Oncology, David Geffen School of Medicine at UCLA, B3-109 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095-1714, USA. dschaue@mednet.ucla.edu

International Journal of Radiation Oncology, Biology, Physics
|January 3, 2012
PubMed
Summary

Radiation dose and fraction size significantly impact antitumor immunity and tumor control. Optimal fractionated doses enhance anti-tumor responses while minimizing suppressive immune cells, suggesting radiation can act as an immune adjuvant.

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