Related Experiment Video
Updated: May 26, 2026
The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer
Published on: June 21, 2019
[Primary choriocarcinoma of the maxillary gingival]
A Khanfir1, T Kaffel, N Gouiaa
1Service d'Oncologie Médicale, CHU Habib-Bourguiba, 3029 Sfax, Tunisie. afefkhanfir@yahoo.fr
Introduction:
Primary non-gestational extragonadal choriocarcinomas are uncommon and their head and neck localization more exceptional.
Observation:
We report on a primary choriocarcinoma case of the mandibular gingivae in a 26-year-old woman who presented with pulmonary and renal metastasis. Complete response (clinical, biological and radiological) was achieved with combined chemotherapy according to APE regimen associating actinomycin, cisplatin and etoposid. The patient was free of disease 4 years after therapy completion.
Discussion:
Primary gingival mandibular choriocarcinoma is very rare. Clinical presentation is atypical; diagnosis is based on histopathological examination and positivity for HCG. Our case report showed high chemo-sensitivity and comparable outcome to the other localizations.
