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Related Concept Videos

Larynx01:21

Larynx

The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Mechanism of Breathing III: The Accessory Muscles01:21

Mechanism of Breathing III: The Accessory Muscles

The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
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Mechanism of Breathing I: Inspiration01:30

Mechanism of Breathing I: Inspiration

Introduction to Inspiration: The Respiratory System in Action
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Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

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The Larynx
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Related Experiment Video

Updated: May 26, 2026

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
10:16

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication

Published on: December 2, 2011

A canonical biomechanical vocal fold model.

Pinaki Bhattacharya1, Thomas H Siegmund

  • 1School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.

Journal of Voice : Official Journal of the Voice Foundation
|January 3, 2012
PubMed
Summary

Creating a simplified human vocal fold (VF) geometry is possible. Optimal abstraction balances geometric detail and mechanical response accuracy for better VF modeling.

Area of Science:

  • Biomechanics
  • Computational Modeling
  • Human Anatomy

Background:

  • Accurate computational models of human vocal folds (VF) are crucial for understanding voice production and pathology.
  • Existing models often lack subject-specific geometric detail or are overly complex.
  • Developing simplified, yet accurate, VF models is essential for clinical and research applications.

Purpose of the Study:

  • To construct a canonical geometry of the human vocal fold (VF) from subject-specific image data.
  • To automate the VF model construction process using computer-aided design.
  • To evaluate the impact of geometric abstraction on the mechanical response of VF models.

Main Methods:

  • Subject-specific VF geometry data was used to create computational models.

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Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

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Last Updated: May 26, 2026

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
10:16

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication

Published on: December 2, 2011

Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models
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Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models

Published on: January 5, 2024

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Published on: August 1, 2014

  • Three levels of geometric abstraction were derived from the subject-specific model.
  • A quasi two-dimensional VF model geometry was also utilized for comparison.
  • Natural frequencies were calculated for each model across a range of biomechanical properties.
  • Main Results:

    • Increased geometric abstraction led to greater deviation in predicted natural frequencies (up to 50%).
    • An optimally abstracted 'canonical' model matched the subject-specific baseline response after recalibration.
    • Highly abstracted models and the quasi-two-dimensional model showed significant frequency response deviations.
    • The quasi-two-dimensional model could not be recalibrated to match the subject-specific model due to complex boundary conditions.

    Conclusions:

    • Automated construction of canonical VF models from subject-specific imaging is feasible.
    • Optimal geometric abstraction is key to balancing model simplification and mechanical accuracy.
    • The proposed canonical model approach enhances the realizability of subject-specific VF modeling.