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Perfusion CT in childhood stroke--initial observations and review of the literature

D Zebedin1, E Sorantin, M Riccabona

  • 1Division of Pediatric Radiology, Department of Radiology, University Hospital LKH Graz, Austria. doris.zebedin@medunigraz.at

European Journal of Radiology
|January 3, 2012
PubMed

Insights

Contrast-enhanced perfusion CT effectively diagnoses perfusion disturbances in children suspected of stroke, showing high accuracy. This advanced imaging technique improves diagnostic capability in emergency pediatric stroke evaluations.

Area of Science:

  • Pediatric Radiology
  • Neuroradiology
  • Medical Imaging

Background:

  • Childhood stroke diagnosis presents challenges.
  • Perfusion disturbances are key indicators of ischemic events.
  • Advanced imaging is crucial for timely and accurate diagnosis in pediatric patients.

Purpose of the Study:

  • To evaluate the preliminary results of contrast-enhanced perfusion multi-detector CT (CTP) for diagnosing perfusion disturbances in children with suspected stroke.
  • To assess the diagnostic accuracy and image quality of CTP compared to other imaging modalities.

Main Methods:

  • Retrospective review of CTP, CT-digital subtraction angiography (CT-DSA), and CT-angiography (CTA) in ten children (age 8-17) with suspected stroke.
  • Comparison with MRI, follow-up CT, catheter angiography, and clinical diagnosis.
  • Subjective evaluation of image quality for perfusion maps and vessel depiction.

Main Results:

  • CTP demonstrated high accuracy, with no false positives or negatives in nine out of ten children.
  • One case of focal hypoperfusion in a child with migraine was initially suspected as stroke but ruled out by MRI/MRA.
  • Perfusion-CT with CT-DSA achieved very good ratings in 80% of cases for detecting perfusion disturbances and vessel anatomy.

Conclusions:

  • Contrast-enhanced perfusion CT significantly enhances the diagnostic capability of standard CT in emergency evaluations for suspected pediatric ischemic cerebral infarction.
  • CTP offers a valuable tool for identifying perfusion deficits in the pediatric population.
  • This technique aids in the rapid and accurate diagnosis of stroke in children.
Abstract

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