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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
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Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
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Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Molecular and Ionic Solids

Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...

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Related Experiment Video

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Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
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Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

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Nucleic acid-metal ion interactions in the solid state.

Katsuyuki Aoki1, Kazutaka Murayama

  • 1Department of Materials Science, Toyohashi University of Technology, Tempaku-cho, Toyohashi, Japan. kaoki@tutms.tut.ac.jp

Metal Ions in Life Sciences
|January 3, 2012
PubMed
Summary

This review updates knowledge on metal ion interactions with nucleic acids, focusing on crystal structures reported after 1994. It reveals new metal-binding patterns in DNA and RNA duplexes, crucial for understanding nucleic acid functions.

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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Area of Science:

  • Biochemistry
  • Structural Biology
  • Biophysical Chemistry

Background:

  • Metal ions are crucial for nucleic acid structure and function.
  • Understanding metal ion binding rules is essential for elucidating nucleic acid activities.
  • This review updates a 1996 overview of metal ion interactions with nucleic acids.

Purpose of the Study:

  • To survey crystal structures of metal ion complexes with nucleotides and oligonucleotides reported after 1994.
  • To uncover novel metal-binding patterns in mononucleotides and oligonucleotide duplexes (A-RNA, A/B/Z-DNA).
  • To discuss factors influencing metal binding to nucleic acid duplexes.

Main Methods:

  • Comprehensive literature survey of crystal structures reported post-1994.
  • Analysis of metal ion coordination in mononucleotides and oligonucleotide duplexes.
  • Focus on A-RNA and A/B/Z-DNA duplex structures.

Main Results:

  • Identification of new characteristic metal bonding patterns for mononucleotides and oligonucleotides.
  • Detailed analysis of metal ion interactions within A-RNA and A/B/Z-DNA duplexes.
  • Compilation of structural data on metal-nucleic acid complexes.

Conclusions:

  • The study provides updated insights into metal ion binding modes with nucleic acids.
  • New bonding patterns enhance understanding of metal ion roles in nucleic acid structure and activity.
  • This work serves as a valuable resource for researchers in nucleic acid-metal ion interactions.