Paths and ways of epilepsy

The importance assigned to different brain sites for the initiation and conduction of epileptic activity has changed with times, the significant zones being somehow alternatively the cerebral cortex and various centrencephalic structures. Rather than renew this controversy, the available experimental evidence indicating that for the production of epilepsy, the entire brain, or at least several structures and not only discrete cortical or subcortical focal areas must participate, is critically reviewed.