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Role of vitamin d supplementation in hypertension

R K Goel1, Harbans Lal

  • 1Departments of Medicine and Biochemistry, Maharaja Agrasen Medical College, Hisar, Agroha, 125047 Haryana India.

Indian Journal of Clinical Biochemistry : IJCB
|January 3, 2012
PubMed

Insights

Vitamin D supplementation significantly reduced systolic blood pressure in hypertensive patients. This study suggests combining Vitamin D with standard hypertension treatments may improve outcomes.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Hypertension is a major global health concern.
  • The role of Vitamin D in cardiovascular health is an area of ongoing research.
  • Vitamin D deficiency is prevalent in many populations, including those with hypertension.

Purpose of the Study:

  • To investigate the effect of Vitamin D supplementation on blood pressure in hypertensive patients.
  • To assess the impact of Vitamin D on serum calcium, phosphorous, and related markers.
  • To determine if Vitamin D can be a beneficial adjunct to conventional antihypertensive therapy.

Main Methods:

  • A randomized controlled trial involving 200 hypertensive patients.
  • Group I received conventional antihypertensive drugs.
  • Group II received conventional drugs plus Vitamin D3 (33,000 IU bi-weekly for 3 months).
  • Blood pressure and biochemical parameters (serum calcium, phosphorous, albumin, albumin-corrected calcium, urinary creatinine) were measured before and after treatment.

Main Results:

  • Vitamin D supplementation led to a more significant reduction in systolic blood pressure compared to conventional therapy alone.
  • Patients receiving Vitamin D showed increased serum calcium and albumin-corrected calcium levels.
  • A significant decrease in serum phosphorous was observed in the Vitamin D supplemented group.

Conclusions:

  • Vitamin D supplementation plays a role in reducing blood pressure in hypertensive individuals.
  • Combining Vitamin D with antihypertensive drugs may enhance treatment efficacy.
  • Further extensive studies with larger cohorts are warranted to solidify these findings.

Keywords:
Blood pressureHypertensionVitamin D supplementation

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