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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

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Published on: February 28, 2019

Decreased Expression of FOXP3 in Nasal Polyposis.

Kannika Roongrotwattanasiri¹, Ruby Pawankar, Satoko Kimura

¹Rhinology and Allergy, Nippon Medical School, Tokyo, Japan.

Allergy, Asthma & Immunology Research

|January 3, 2012

Summary

Nasal polyposis (NP) shows fewer regulatory T cells (Tregs) expressing FOXP3 compared to allergic rhinitis. This Treg deficiency may explain the heightened Th2 inflammation characteristic of NP.

Keywords:

FOXP3 IgE Nasal polyposis Th2 inflammation regulatory T cells

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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

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Published on: January 22, 2020

Area of Science:

Immunology
Otorhinolaryngology
Allergy Research

Background:

Nasal polyposis (NP) pathogenesis is not fully understood, though eosinophils, mast cells, and Th2-type cells are implicated.
High levels of chemokines like CCL17 and RANTES are observed in NP patients.
Regulatory T cells (Tregs), marked by FOXP3 expression, are crucial for immune balance and are decreased in allergic diseases.

Purpose of the Study:

To investigate the presence and role of FOXP3+ regulatory T cells (Tregs) in nasal polyposis (NP).
To compare Treg numbers in NP patients with those in allergic rhinitis (AR) patients.
To determine if Treg levels differ between atopic and non-atopic NP.

Main Methods:

Immunohistochemistry was used to quantify FOXP3+ cells in nasal polyps (NP) and nasal mucosa from allergic rhinitis (AR) patients.
The study included 17 NP patients and 15 AR patients.
FOXP3+ cell counts were compared between NP and AR tissues, and within NP groups (atopic vs. non-atopic).

Main Results:

Significantly lower numbers of FOXP3+ cells were found in the lamina propria of NP tissues compared to AR nasal mucosa (2.79 vs. 5.99, P=0.008).
Epithelial FOXP3+ cell counts did not differ significantly between NP and AR tissues (3.60 vs. 2.39, P=0.180).
CD4+FOXP3+ cell counts were lower in NP than in allergic nasal mucosa, with no difference between atopic and non-atopic NP.

Conclusions:

Nasal polyposis exhibits a reduction in regulatory T cells (Tregs) expressing FOXP3 compared to allergic rhinitis.
The decreased Treg presence in NP may correlate inversely with the severity of eosinophilic, Th2-type inflammation.
A deficiency in Tregs could contribute to the more pronounced Th2-type inflammation observed in nasal polyposis.