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Updated: May 26, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
Dissociation, PTSD, and substance abuse: an empirical study
Lisa M Najavits1, Marybeth Walsh
1McLean Hospital, Belmont, Massachusetts, USA. Lnajavits@hms.harvard.edu
Women with high dissociation and posttraumatic stress disorder (PTSD) show greater impairment in substance use and trauma symptoms. Dissociation is a significant factor even with substance use disorders.
Area of Science:
- Psychology
- Psychiatry
- Neuroscience
Background:
- Posttraumatic stress disorder (PTSD), substance use disorder (SUD), and dissociation are frequently comorbid.
- Few studies have explored the interplay between these conditions, particularly in women.
Purpose of the Study:
- To investigate the relationship between PTSD, SUD, and dissociation in women.
- To compare the clinical profiles of women with PTSD and SUD based on dissociation levels.
Main Methods:
- Seventy-seven women with current PTSD and substance dependence were assessed.
- Participants were categorized into high- and low-dissociation groups using the Dissociative Experiences Scale.
- Comparisons were made on trauma-related symptoms, substance use, cognitions, coping skills, social adjustment, trauma history, psychiatric symptoms, and self-harm/suicidal behaviors.
Main Results:
- The high-dissociation group exhibited significantly greater impairment across multiple domains compared to the low-dissociation group.
- High levels of dissociation were prevalent in the sample, irrespective of recent substance use.
- Individuals in the high-dissociation group reported a stronger belief in substances' ability to manage psychiatric symptoms.
- The high-dissociation group reported more trauma-related symptoms and a history of childhood emotional abuse and physical neglect.
Conclusions:
- Dissociation is a critical factor influencing the severity of symptoms and impairment in women with comorbid PTSD and SUD.
- The findings support the need for integrated treatment approaches addressing both trauma and dissociation in individuals with substance use disorders.
- Further research is warranted to understand the "chemical dissociation" hypothesis and the nuanced experience of substances in relation to dissociative phenomena.
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