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Updated: May 26, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Platelet-activating factor does not mediate UVB-induced local immune suppression.

Ravi P Sahu1, Yongxue Yao, Raymond L Konger

  • 1Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Photochemistry and Photobiology
|January 4, 2012
PubMed
Summary

Platelet-activating factor receptor (PAF-R) is crucial for systemic immunosuppression after UVB exposure. However, UVB-induced local immunosuppression and Langerhans cell reduction occur independently of PAF-R signaling.

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Area of Science:

  • Immunology
  • Dermatology
  • Photobiology

Background:

  • UVB irradiation induces both systemic and local immunosuppression.
  • Platelet-activating factor (PAF) and its agonists are implicated in UVB-mediated systemic immunosuppression.
  • Systemic immunosuppression by UVB is dependent on the PAF receptor (PAF-R) in wild-type (WT) mice, but not in PAF-R-knockout (Pafr-/-) mice.

Purpose of the Study:

  • To investigate the role of the PAF receptor (PAF-R) in UVB-induced local immunosuppression.
  • To compare the effects of locally applied UVB on contact hypersensitivity (CHS) responses in WT and Pafr-/- mice.

Main Methods:

  • Contact hypersensitivity (CHS) was induced using dinitrofluorobenzene (DNFB).
  • Local UVB irradiation was applied to specific skin areas in WT and Pafr-/- mice.

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  • Langerin expression, a marker for Langerhans cells, was assessed in epidermal ear skin.

    • Main Results:

    • Local UVB irradiation significantly inhibited CHS responses in both WT and Pafr-/- mice compared to controls.
    • UVB exposure equally reduced Langerhans cell populations in both WT and Pafr-/- mice.
    • These results indicate that PAF-R signaling is not involved in local UVB-induced immunosuppression.

    Conclusions:

    • The PAF receptor is not required for UVB-induced local immunosuppression.
    • UVB-mediated reduction in Langerhans cells is independent of PAF-R signaling.
    • These findings differentiate the mechanisms of systemic and local immunosuppression induced by UVB.