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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: May 26, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Rippled-pattern basal cell carcinoma.

Noriyuki Misago1, Noriko Tsuruta, Yutaka Narisawa

  • 1Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. misago@post.saga-med.ac.jp

The Journal of Dermatology
|January 4, 2012
PubMed
Summary

This study details a rare "rippled pattern" in basal cell carcinoma (BCC), a common skin cancer. The rare variant features unique histopathological characteristics, distinguishing it from similar conditions.

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Cell Population Analyses During Skin Carcinogenesis
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Cell Population Analyses During Skin Carcinogenesis

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Related Experiment Videos

Last Updated: May 26, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is the most prevalent malignant cutaneous neoplasm.
  • Studies investigating BCC with a "rippled pattern" are scarce.

Observation:

  • A single case of BCC exhibiting a "rippled pattern" was identified among 650 BCC specimens.
  • The rippled pattern was characterized by alternating bands of spindle-shaped basaloid cell cords and mucinous spaces.

Findings:

  • The rippled-pattern BCC was of the nodular type.
  • Histopathological features included frequent mucinous spaces between epithelial cords and no apparent divergent differentiation.
  • Neoplastic germinative cells formed cord-like structures, resembling rippled-pattern sebaceoma/trichoblastoma.

Implications:

  • The distinct histopathological features aid in differentiating rippled-pattern BCC from sebaceoma/trichoblastoma.
  • Understanding these characteristics is crucial for accurate diagnosis and classification of rare BCC variants.