Related Experiment Video

Updated: May 26, 2026

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid
07:24

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

Newcastle disease virus: a promising agent for tumour immunotherapy

Lixiang Zhao1, Haiyan Liu

  • 1Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.

Clinical and Experimental Pharmacology & Physiology
|January 4, 2012
PubMed

Insights

Newcastle disease virus (NDV) shows promise as a cancer immunotherapy, offering an effective alternative to traditional treatments. This virotherapy approach leverages NDV's oncolytic effects and ability to stimulate anti-tumor immune responses with fewer side effects.

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Malignant tumors are a leading cause of human mortality.
  • Current cancer therapies have limited efficacy and significant side effects.
  • Newcastle disease virus (NDV) presents a novel therapeutic strategy for cancer immunotherapy.

Purpose of the Study:

  • To review the mechanisms and advancements in NDV-based virotherapy for cancer treatment.
  • To highlight the oncolytic potential and immunomodulatory effects of NDV.
  • To discuss the development of recombinant NDV strains for enhanced therapeutic properties.

Main Methods:

  • Review of existing scientific literature on NDV and cancer.
  • Analysis of studies investigating NDV's oncolytic mechanisms.
  • Examination of clinical trial data for NDV in cancer therapy.
  • Exploration of advancements in reverse genetics for NDV engineering.

Main Results:

  • NDV exhibits significant oncolytic effects against various tumors.
  • NDV can induce both innate and adaptive anti-tumor immune responses.
  • Clinical trials suggest NDV virotherapy has a favorable side-effect profile compared to conventional treatments.
  • Recombinant NDV strains demonstrate improved oncolytic and immune regulatory capabilities.

Conclusions:

  • NDV is a promising candidate for cancer virotherapy.
  • NDV's efficacy stems from direct oncolysis and immune stimulation.
  • Advancements in genetic engineering are enhancing NDV's therapeutic potential for malignancies.

More Related Videos

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...