Related Experiment Video

Updated: May 26, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Markers of systemic inflammation in children with hyperuricemia

Anna Wasilewska1, Edyta Tenderenda, Katarzyna Taranta-Janusz

  • 1Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland. annwasil@interia.pl

Acta Paediatrica (Oslo, Norway : 1992)
|January 4, 2012
PubMed

Insights

Serum monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity C-reactive protein (hs-CRP) are elevated in children with hyperuricemia. Obesity may influence these inflammation markers, warranting further research.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Chemistry
  • Inflammation Research

Background:

  • Hyperuricemia is linked to metabolic disturbances in children.
  • Inflammation plays a role in the pathogenesis of hyperuricemia and associated conditions.
  • Obesity is a growing concern in pediatric populations and is associated with chronic inflammation.

Purpose of the Study:

  • To investigate serum concentrations of monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity C-reactive protein (hs-CRP) in children with hyperuricemia.
  • To evaluate the association between these inflammation markers and obesity in pediatric hyperuricemia.

Main Methods:

  • Study included 52 hyperuricemic children and 27 healthy controls.
  • Serum MCP-1 and hs-CRP levels were measured using ELISA and immunonephelometry.
  • Body mass index Z-score was used to assess obesity status.

Main Results:

  • Hyperuricemic patients exhibited significantly higher serum MCP-1 and hs-CRP levels compared to controls (p < 0.01).
  • Obese children, both hyperuricemic and non-obese, showed elevated MCP-1 and hs-CRP levels (p < 0.01).
  • hs-CRP showed a positive correlation with body mass index Z-score (r = 0.33, p < 0.05).

Conclusions:

  • Serum MCP-1 and hs-CRP are elevated in children with hyperuricemia.
  • Obesity appears to be associated with increased inflammation markers in this population.
  • Further research is needed to elucidate the precise role of obesity in modulating inflammation markers in pediatric hyperuricemia.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.