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Updated: May 26, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Interactions between metabolism and circadian clocks: reciprocal disturbances
Julien Delezie1, Etienne Challet
1Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, Centre National de la Recherche Scientifique, UPR3212, University of Strasbourg, Strasbourg, France.
Annals of the New York Academy of Sciences
|January 4, 2012
Summary
Altered circadian rhythms contribute to obesity by disrupting metabolic processes in the body. Restoring circadian alignment through chronotherapy may help manage metabolic risks associated with obesity.
Area of Science:
- Metabolic disorders and chronobiology.
Background:
- Obesity is a global epidemic driven by genetics, diet, and lifestyle.
- Altered circadian rhythmicity is an emerging factor contributing to obesity.
- The body possesses a central circadian clock in the suprachiasmatic nucleus (SCN) and peripheral clocks in tissues like the liver and adipose tissue.
Purpose of the Study:
- To review evidence linking metabolic dysfunction with circadian disturbances.
- To explore how disrupted circadian clock function contributes to obesity.
- To illustrate the transcriptional crosstalk between metabolic and circadian systems.
Main Methods:
- Review of scientific literature on circadian rhythms and metabolic health.
- Analysis of the reciprocal interactions between circadian and metabolic systems.
- Examination of transcriptional crosstalk mechanisms.
Main Results:
- Metabolic dysfunction is associated with both central and peripheral circadian disturbances.
- Disruption of circadian clock function can lead to obesity.
- Transcriptional crosstalk underlies the interplay between metabolic and circadian systems.
Conclusions:
- Circadian rhythmicity plays a crucial role in metabolic regulation.
- Chronotherapeutic interventions, such as timed dieting, may help manage obesity and metabolic risks.
- Maintaining circadian alignment is vital for metabolic health.
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