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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Meiosis II01:57

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...

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Related Experiment Video

Updated: May 26, 2026

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

A plea for a more physiological ICSI.

T Ebner1, M Filicori, G Tews

  • 1Landes- Frauen- und Kinderklinik, Kinderwunsch Zentrum, Linz, Upper Austria, Austria. Thomas.ebner@gespag.at

Andrologia
|January 4, 2012
PubMed
Summary
This summary is machine-generated.

Intracytoplasmic sperm injection (ICSI) offers a revolutionary treatment for male infertility. New techniques aim to minimize risks by selecting healthier sperm, potentially preventing long-term side effects in adults conceived via ICSI.

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Last Updated: May 26, 2026

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Male Infertility

Background:

  • Intracytoplasmic sperm injection (ICSI) is a key treatment for male factor infertility.
  • Long-term effects of ICSI on adults are largely unknown.
  • Potential risks include fertilization by spermatozoa with defective nuclear content.

Purpose of the Study:

  • To review recent advances in performing ICSI safely.
  • To minimize theoretical hazards associated with the procedure.
  • To provide recommendations for selecting optimal spermatozoa for ICSI.

Main Methods:

  • Literature search of Medline and Embase databases (1996-2011).
  • Analysis of recent technical advancements in ICSI.
  • Evaluation of sperm selection markers and imaging techniques.

Main Results:

  • Technical advances allow for simulation of physiological conditions during ICSI.
  • Sperm selection based on motility and maturation markers (e.g., hyaluronic acid) may prevent fertilization by damaged spermatozoa.
  • Non-invasive imaging techniques can aid in morphological sperm selection.

Conclusions:

  • ICSI can be performed more safely with current technological advancements.
  • Selecting spermatozoa based on specific markers can reduce theoretical risks.
  • Further research is needed to fully understand and mitigate long-term effects.