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EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: May 26, 2026

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Published on: May 1, 2019

Progress toward generating informative porcine biomedical models using induced pluripotent stem cells.

Franklin West¹, Steven Stice

¹ADS Department, University of Georgia Regenerative Bioscience Center, University of Georgia, Athens, Georgia, USA.

Annals of the New York Academy of Sciences

|January 4, 2012

Summary

Porcine induced pluripotent stem cells offer potential for human regenerative medicine and large animal disease modeling. These stem cells are valuable tools for advancing biomedical research and therapeutic development.

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Generation of Mice Derived from Induced Pluripotent Stem Cells

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

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Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors

Published on: May 1, 2019

Generation of Mice Derived from Induced Pluripotent Stem Cells

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Area of Science:

Stem cell biology
Regenerative medicine
Animal models

Background:

Porcine induced pluripotent stem cells (piPSCs) are a promising cell source.
Large animal models are crucial for translational research.

Purpose of the Study:

To highlight the potential of piPSCs.
To discuss their applications in regenerative medicine and disease modeling.

Main Methods:

Review of existing literature on piPSCs.
Analysis of potential applications.

Main Results:

piPSCs show pluripotency and differentiation capacity.
They can be used to model human diseases.

Conclusions:

piPSCs are valuable for regenerative medicine.
They serve as effective translational large animal disease models.