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A knockout mouse resource for the biomedical research community.

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The Knockout Mouse Project (KOMP) Repository provides essential resources, including mutant mice and stem cell clones, for 8,500 knockout genes. This repository facilitates genetic research by archiving and distributing valuable biological materials.

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Area of Science:

  • Genetics
  • Genomics
  • Developmental Biology

Background:

  • The Knockout Mouse Project (KOMP) aims to generate knockout mouse models for all protein-coding genes.
  • A centralized repository is crucial for the efficient distribution and archiving of these valuable research tools.

Purpose of the Study:

  • To describe the establishment and operational functions of the KOMP Repository.
  • To highlight the resources available for the scientific community.

Main Methods:

  • Archiving of vectors, embryonic stem cell clones, and frozen germplasm.
  • Distribution of live mutant mice generated through the KOMP initiative.
  • Maintenance of a comprehensive database of available knockout resources.

Main Results:

  • The KOMP Repository successfully archives and distributes resources for 8,500 knockout genes.
  • A wide array of biological materials, including live mutant mice, are made available.

Conclusions:

  • The KOMP Repository is a vital resource supporting genetic research worldwide.
  • The repository's functions streamline access to knockout mouse models, accelerating biological discovery.