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Humanized mice as a preclinical tool for infectious disease and biomedical research

Leonard D Shultz1, Michael A Brehm, Sina Bavari

  • 1The Jackson Laboratory, Bar Harbor, Maine, USA. lenny.shultz@jax.org

Annals of the New York Academy of Sciences
|January 4, 2012
PubMed

Abstract:

Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

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