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Updated: May 26, 2026

07:32
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
Humanized mice as a preclinical tool for infectious disease and biomedical research
Leonard D Shultz1, Michael A Brehm, Sina Bavari
1The Jackson Laboratory, Bar Harbor, Maine, USA. lenny.shultz@jax.org
Annals of the New York Academy of Sciences
|January 4, 2012
Abstract:
Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

