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Animal models got you puzzled?: think pig.

Eric M Walters1, Yuksel Agca, Venkataseshu Ganjam

  • 1National Swine Resource and Research Center, University of Missouri, Columbia, Missouri, USA. walterse@missouri.edu

Annals of the New York Academy of Sciences
|January 4, 2012
PubMed
Summary

Swine serve as valuable large animal models for studying human diseases due to physiological similarities. Emerging technologies further support their use as a preferred nonrodent model in biomedical research.

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Area of Science:

  • Biomedical research
  • Animal models

Background:

  • Swine share significant physiological and anatomical similarities with humans.
  • These similarities are particularly evident in organ systems like the skin, heart, gastrointestinal tract, and kidneys.
  • The pig is increasingly recognized as a suitable nonrodent model for human health and disease research.

Purpose of the Study:

  • To highlight the utility of swine as a large animal model in biomedical research.
  • To underscore the physiological parallels between swine and humans.
  • To emphasize the role of emerging technologies in advancing swine as a nonrodent model.

Main Methods:

  • Comparative physiology analysis.
  • Review of existing biomedical research utilizing swine models.

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  • Assessment of technological advancements impacting swine model development.

    • Main Results:

    • Swine exhibit remarkable physiological and anatomical congruence with humans.
    • Key organ systems in swine, including skin, heart, gastrointestinal tract, and kidneys, closely resemble human counterparts.
    • Technological advancements are enhancing the capabilities and applications of swine in biomedical research.

    Conclusions:

    • Swine represent a highly valuable large animal model for human health and disease research.
    • Their physiological relevance and ongoing technological enhancements solidify their position as a leading nonrodent model.
    • Further development and utilization of swine models are crucial for advancing biomedical science.